High-Sensitivity Analysis of Crystallinity in Respirable Powders Using Low Frequency Shift-Raman Spectroscopy
نویسندگان
چکیده
منابع مشابه
Red-excitation dispersive Raman spectroscopy is a suitable technique for solid-state analysis of respirable pharmaceutical powders.
Dispersive Raman spectroscopy with excitation by a red diode laser is suitable for quantitative crystallinity measurements in powders for pulmonary drug delivery. In spray-dried mixtures of salmon calcitonin and mannitol, all three crystalline polymorphs of mannitol and amorphous mannitol were unambiguously identified and their mass fractions were measured with a limit of quantification of abou...
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